Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus

Léa Meneu^†, Christophe Chapard^†, Jacques Serizay^†, Alex Westbrook, Etienne Routhier, Myriam Ruault, Manon Perrot, Alexandros Minakakis, Fabien Girard, Amaury Bignaud, Antoine Even, Géraldine Gourgues, Domenico Libri, Carole Lartigue, Aurèle Piazza, Agnès Thierry, Angela Taddei, Frédéric Beckouët, Julien Mozziconacci, Romain Koszul

^† Equal contribution

Science387(6734): eadm9466 1 February 2025

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Abstract

The composition of genomic sequences, such as GC content, nucleotide motifs, and repeats, varies from one species to another and within the same genome. Composition correlates with gene transcriptional activity and chromosome organization, and all genome sequences have coevolved with the chromatin-associated complexes they encode to precisely regulate these two features. However, when foreign DNA—including exogenous mobile elements and natural or artificial genesinvades or integrates a host nucleus, it encounters regulatory mechanisms and rules under which it has not evolved. How host cells process and eventually adopt these unfamiliar exogenous sequences remains largely unexplored.

Cite

Meneu L, Chapard C, Serizay J, Westbrook A, Routhier E, Ruault M, et al. Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus. Science. 2025;387(6734):eadm9466. doi:10.1126/science.adm9466

@article{meneu_science_2025,
  author  = {Meneu, Léa and Chapard, Christophe and Serizay, Jacques and Westbrook, Alex and Routhier, Etienne and Ruault, Myriam and Perrot, Manon and Minakakis, Alexandros and Girard, Fabien and Bignaud, Amaury and Even, Antoine and Gourgues, Géraldine and Libri, Domenico and Lartigue, Carole and Piazza, Aurèle and Thierry, Agnès and Taddei, Angela and Beckouët, Frédéric and Mozziconacci, Julien and Koszul, Romain},
  title   = {{Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus}},
  journal = {Science},
  year    = {2025},
  volume  = {387},
  number  = {6734},
  pages   = {eadm9466},
  doi     = {10.1126/science.adm9466},
  url     = {https://doi.org/10.1126/science.adm9466}
}

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